Summary

Dataset 1

Experiments excluded

Mask

Get figure file: figures/preliminary_dset-1_figure-mask.png

Peak coordinates

Get figure file: figures/preliminary_dset-1_figure-static.png
Get figure file: figures/preliminary_dset-1_figure-legend.png

Explorer

Meta-Analysis

Estimator

Parameters use to fit the meta-analytic estimator.

Corrector

Parameters use to fit the corrector.

Corrected meta-analytic map: z_corr-FDR_method-indep

Explorer

The following figure provides an interactive window to explore the meta-analytic map in detail.

Slice viewer

This panel shows the the corrrected meta-analytic map.

Get figure file: figures/corrector_figure-static.png

Diagnostics

Target image: z_corr-FDR_method-indep

Significant clusters

    X Y Z Peak Stat Cluster Size (mm3)
Tail Cluster ID          
Positive 1 0.00 -56.00 28.00 9.14 12112
1a -8.00 -54.00 10.00 3.07
1b 2.00 -52.00 48.00 3.07
1c -12.00 -56.00 10.00 2.82
2 -48.00 -70.00 8.00 7.98 31040
2a -48.00 -58.00 20.00 7.78
2b -56.00 -50.00 18.00 6.65
2c -54.00 -46.00 8.00 5.20
3 46.00 -70.00 -4.00 7.23 54504
3a 50.00 -66.00 4.00 7.04
3b 58.00 -48.00 16.00 6.65
3c 52.00 -62.00 12.00 6.24
4 38.00 24.00 -6.00 7.23 25152
4a 32.00 22.00 2.00 5.63
4b 54.00 30.00 8.00 5.63
4c 48.00 26.00 0.00 5.42
5 -36.00 20.00 -4.00 6.85 25120
5a -42.00 24.00 -14.00 5.83
5b -32.00 18.00 -6.00 5.83
5c -40.00 24.00 -6.00 5.83
6 -4.00 56.00 12.00 6.24 36736
6a -6.00 50.00 -4.00 6.03
6b 0.00 50.00 -12.00 6.03
6c 0.00 52.00 20.00 6.03
7 -26.00 -4.00 56.00 4.54 7328
7a -48.00 4.00 32.00 3.82
7b -40.00 12.00 30.00 3.07
7c -44.00 4.00 38.00 3.07
8 -34.00 -58.00 -18.00 4.06 4856
8a -42.00 -58.00 -20.00 3.82
8b -34.00 -54.00 -14.00 3.82
8c -42.00 -54.00 -24.00 3.58
9 26.00 -2.00 -20.00 3.82 2184
9a 18.00 -2.00 -16.00 2.82
9b 28.00 -8.00 -16.00 2.82
9c 34.00 0.00 -26.00 2.04
10 -6.00 -90.00 2.00 3.58 2080
10a -2.00 -84.00 -2.00 3.32
10b -10.00 -92.00 2.00 2.82
10c -2.00 -80.00 2.00 2.82
11 -4.00 -16.00 44.00 3.32 1736
11a -6.00 -14.00 34.00 2.56
11b 4.00 -16.00 40.00 2.56
11c -2.00 -10.00 40.00 2.30
12 -6.00 -12.00 4.00 2.82 664
13 -14.00 8.00 0.00 2.82 832
14 40.00 -32.00 46.00 2.82 864
14a 40.00 -30.00 56.00 2.56
14b 42.00 -36.00 50.00 2.30
14c 42.00 -28.00 46.00 2.30
15 12.00 -20.00 6.00 2.82 1016
15a 0.00 -12.00 6.00 2.56
15b 10.00 -12.00 8.00 2.56
15c 18.00 -20.00 6.00 2.56
16 -4.00 16.00 -4.00 2.56 328
17 -22.00 -4.00 -18.00 2.56 632
18 26.00 -60.00 54.00 2.56 512
18a 22.00 -56.00 60.00 2.30
19 8.00 -90.00 28.00 2.30 232
20 -30.00 -66.00 42.00 2.04 128
21 14.00 16.00 -2.00 2.04 128
22 12.00 -24.00 -8.00 2.04 80

Label map: positive tail

Get figure file: figures/diagnostics_tail-positive_figure.png

FocusCounter

The FocusCounter analysis characterizes the relative contribution of each experiment in a meta-analysis to the resulting clusters by counting the number of peaks from each experiment that fall within each significant cluster.

The heatmap presents the relative contributions of each experiment to each cluster in the thresholded map. There is one row for each experiment, and one column for each cluster, with column names being PostiveTail/NegativeTail indicating the sign (+/-) of the cluster's statistical values. The rows and columns were re-ordered to form clusters in the heatmap.

Heatmap: positive tail

Methods

We kindly ask to report results preprocessed with this tool using the following boilerplate.

A multilevel kernel density (MKDA) meta-analysis \citep{wager2007meta} was performed was performed
with NiMARE 0.6.0+6.g55f7ea1 (RRID:SCR_017398; \citealt{Salo2023}), using a(n) MKDA kernel. An MKDA
kernel \citep{wager2007meta} was used to generate study-wise modeled activation maps from
coordinates. In this kernel method, each coordinate is convolved with a sphere with a radius of
10.0 and a value of 1. For voxels with overlapping spheres, the maximum value was retained. Summary
statistics (OF values) were converted to p-values using an approximate null distribution. The input
dataset included 4133 foci from 513 experiments. False discovery rate correction was performed with
the Benjamini-Hochberg procedure \citep{benjamini1995controlling}.

Bibliography

@article{Salo2023,
  doi = {10.52294/001c.87681},
  url = {https://doi.org/10.52294/001c.87681},
  year = {2023},
  volume = {3},
  pages = {1 - 32},
  author = {Taylor Salo and Tal Yarkoni and Thomas E. Nichols and Jean-Baptiste Poline and Murat Bilgel and Katherine L. Bottenhorn and Dorota Jarecka and James D. Kent and Adam Kimbler and Dylan M. Nielson and Kendra M. Oudyk and Julio A. Peraza and Alexandre Pérez and Puck C. Reeders and Julio A. Yanes and Angela R. Laird},
  title = {NiMARE: Neuroimaging Meta-Analysis Research Environment},
  journal = {Aperture Neuro}
}
@article{benjamini1995controlling,
  title={Controlling the false discovery rate: a practical and powerful approach to multiple testing},
  author={Benjamini, Yoav and Hochberg, Yosef},
  journal={Journal of the Royal statistical society: series B (Methodological)},
  volume={57},
  number={1},
  pages={289--300},
  year={1995},
  publisher={Wiley Online Library},
  url={https://doi.org/10.1111/j.2517-6161.1995.tb02031.x},
  doi={10.1111/j.2517-6161.1995.tb02031.x}
}
@article{wager2007meta,
  title={Meta-analysis of functional neuroimaging data: current and future directions},
  author={Wager, Tor D and Lindquist, Martin and Kaplan, Lauren},
  journal={Social cognitive and affective neuroscience},
  volume={2},
  number={2},
  pages={150--158},
  year={2007},
  publisher={Oxford University Press},
  url={https://doi.org/10.1093/scan/nsm015},
  doi={10.1093/scan/nsm015}
}